NATIONAL AGRICULTURAL LIBRARY ARCHIVED FILE
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Guidelines and Policies

Revised June 1998

[AWIC][ Overview of Adjuvants ] [ Adjuvants Bibliography ] [ ECVAM Workshop ] [ Production Bibliography ] [ Guidelines and Policies ] [ Books & Proceedings ] [ Companies & Institutes ] [ Websites ] [ Organizations ]


Amyx, H.L. (1987). Control of animal pain and distress in antibody production and infectious disease studies. Journal of the American Veterinary Medical Association 191:1287-1289, ISSN:0003-1488.
NAL call number: 41.8 AM3
Descriptors: non-inflammatory alternatives, Freund's, ribi, injection site, footpads, dosage, restraint.

Balk, R. (1990). Ethical issues of adjuvant use. In: Adjuvants: Advances in Technology and Alternatives to Freund's (Conference Proceedings). The Animal Resources Centre and the Faculty of Graduate Studies and Research, McGill University: Montreal, Quebec, pp. 15-18.
Descriptors: science, ethics, suffering.

Canadian Council on Animal Care (1993). Categories of invasiveness in animal experiments. In: Guide to the Care and Use of Experimental Animals E.D. Olfert, B.M. Cross, and A.A. McWilliam (eds.), 2nd edition, Vol. I, pp.201-202, ISBN:0-919-08718-3.
NAL call number: SF406 C36
Descriptors: distress, pain, discomfort.

Canadian Council on Animal Care (1993). CCAC guidelines on acceptable immunological procedures. In: Guide to the Care and Use of Experimental Animals E.D. Olfert, B.M. Cross, and A.A. McWilliam (eds.), 2nd edition, Vol. I, pp.203, ISBN:0-919-08718-3.

NAL call number: SF406 G85 1993
Descriptors: routes of administration, dosage, induction of ascites fluid, injection sites.

de Leeuw, W.A. and P. de Greeve (October 1996). Production of polyclonal and monoclonal antibodies in the Netherlands. In: Second World Congress on Alternatives and Animal Use in the Life Sciences October 20-24, 1996, Utrecht, The Netherlands, J.B.F. van der Valk and L.F.M. van Zutphen, eds., Alternatives to Laboratory Animals: ATLA 24(Special Issue):182, ISSN:0261-1929.
NAL call number: Z7994.L3A5
Descriptors: abstract, codes of practice, scientific societies, reduction, mice.

Grumstrup-Scott, J. and D.D. Greenhouse (Spring 1988). NIH intramural recommendations for the research use of complete Freund's adjuvant. ILAR News 30(2):9 ISSN:0018-9960.
NAL call number: QL55.A1I43
Descriptors: immunization, footpad, peritoneal exudate, judicious use, inflammatory response.

Hanly, W.C. (January 1995). UIC guidelines for the use of adjuvants in animals. BRL Bulletin (10)1:1-4.
NAL call number: IPSG6428
Descriptors: Freund's, laboratory hazard, dose, emulsion, injection site.

 

Hansson, U. (September/October 1997). In vitro versus in vivo propogation of monoclonal antibodies: a test case for the effectiveness of Swedish ethical review committees. Alternatives to Labo ratory Animals (ATLA) 25(5):517-526, ISSN:0261-1929.
NAL call number: Z7994 L3A5
Descriptors: alternative methods, monoclonal antibodies, ascites, pristane, ethical review system, Sweden.

Hendriksen, C. and E. Claassen (October 1996). Polyclonal and monoclonal antibodies: Guidelines for their production. In: Second World Congress on Alternatives and Animal Use in the Life Sciences October 20-24, 1996, Utrecht, The Netherlands, J.B.F. van der Valk and L.F.M. van Zutphen, eds., Alternatives to Laboratory Animals: ATLA 24(Special Issue):181, ISSN:0261-1929.
NAL call number: Z7994.L3A5
Descriptors: abstract, Freund's Complete Adjuvant, adverse effects, welfare, immunization protocols, chicken egg-yolk antibodies, ascites.

Hendriksen, C., J. Rozing, M. Van Der Kamp, and W. De Leeuw (1996). The production of monoclonal antibodies: Are animals still needed? Alternative to Laboratory Animals: ATLA 24(1):109-110, ISSN:0261-1929.
NAL call number: Z7994 L3A5
Descriptors: monoclonal antibody, production, laboratory animal, alternative method, in vitro.

Jackson, L.R. and J.G. Fox (1995). Institutional policies and guidelines on adjuvants and antibody production. ILAR Journal 37(3):141-152, ISSN:0018-9960.
NAL call number: QL55 A1I43
Descriptors: welfare, recommendations, selection of animals, priming agents, Fruend's adjuvant, alternatives, injection sites.

Kuhlmann, I. Kurth, W., Ruhdel, I. (December 1989). Monoclonal antibodies: in vivo and in vitro production on a laboratory scale, with consideration of the legal aspects of animal protection. Alternative to Laboratory Animals: ATLA 17(2):73-82, ISSN:0261-1929.
NAL call number: Z7994.L3A5
Descriptors: mass production, laboratory scale production, vivo and in vitro methods, animal regulations, German animal protection law, Switzerland, Netherlands, animal testing alternatives, animal welfare.

Marx, U., M.J. Embleton, R. Fischer, F.P. Gruber, et al. (1997). Monoclonal antibody production: The report and recommendations of ECVAM Workshop 23. Alternatives to Laboratory Animals: ATLA 25:121-137, ISSN:0261-1929.
NAL call number: Z7994.L3A5
Descriptors: ascites, pain, hybridoma technology, in vitro production, replacement, refinement, reduction, regulatory aspects.

McGuill, M.W. and Rowan, A.N. (Winter 1989). Refinement of monoclonal antibody production and animal well-being. ILAR News 31(1):7-10, ISSN:0018-9960.
NAL call number: QL55.A1I43
Descriptors: mice, ascites tumors, pristane, distress.

National Institutes of Health (1986). Appendix IV: Recommendations for consideration in the research use of inflammatory agents: Complete Freund's adjuvant (CFA). In: Recommendations for Intramural Research
Descriptors: immunization, footpad, peritoneal exudate.

Office of Laboratory Animal Welfare (OLAW) National Institutes of Health (Winter 1997/1998). Production of monoclonal antibodies using mouse ascites method. .Animal Welfare Information Newsletter 8(3-4):19-20, ISSN:1050-561X.
NAL call number: aHV4701 A952
Descriptors: guidance letter, policy, public laws, pain, distress, alternatives.

Rowan, A.N. (1995). The third R: Refinement. Alternative to Laboratory Animals: ATLA 23:332-346, ISSN:0261-1929.
NAL call number: Z7994 L3A5
Descriptors: alternatives, distress, anxiety, suffering, antibody production.

Straughan, D.W. (October 1996). Prospects for European guidelines for polyclonal and monoclonal antibody production. In: Second World Congress on Alternatives and Animal Use in the Life Sciences October 20-24, 1996, Utrecht, The Netherlands, J.B.F. van der Valk and L.F.M. van Zutphen, eds., Alternatives to Laboratory Animals: ATLA 24(Special Issue):183, ISSN:0261-1929.
NAL call number: Z7994.L3A5
Descriptors: abstract, alternatives, best practice, bleeding, immunization, ascites, humane endpoints.

Toth, L.A., A.W. Dunlap, G.A. Olson, and J.R. Hessler (March 1989). An evaluation of distress following intraperitoneal immunization with Freund's adjuvant in mice. Laboratory Animal Science 39(2):122-126, ISSN:0023-6764.
NAL call number: 410.9 P94
Descriptors: mice, intraperitoneal, food intake, body weight, neutrophilia, granulomatous peritonitis.


[AWIC][ Overview of Adjuvants ] [ Adjuvants Bibliography ] [ ECVAM Workshop ] [ Production Bibliography ] [ Guidelines and Policies ] [ Books & Proceedings ] [ Companies & Institutes ] [ Websites ] [ Organizations ]