A Selected List of
Company and Institute
Providing New Technologies
P.O. Box 1560, Davis, CA 95617, USA
Telephone: (916) 758-4400, Fax: (916) 758-6307
Manufacture monoclonal and polyclonal antibodies, custom antiserums, and diagnostic
kits. Production via cell culture, fermentors, hybridomas, and small reactors.
Antibody Production Centre
Aacademic Business Centre of Leiden University
Niels Bohrweg 11-13 K2, 2333 CA, Leiden, The Netherlands
Telephone: (31)-71-21 54 43 or (31)-71-27 68 62, Fax: (31)-71-21 72 72 (from U.S.
Independent contract house for cell derived monoclonal antibodies. Activities focus on
in vitro cultures. Use hollow fiber bioreactor perfusion systems and have processed over
25 different cell lines.
60 Industrial Park Road
Saco, ME 04072, USA
Telephone: (888) 530-0140 (toll free US only) (207) 283-6500, Fax: (207) 283-4800
Offers custom monoclonal antibody development for research and manufacturing. In vitro
monoclonal antibody production services utilizing bioreactors and serum-free medium.
Ascites production in mice.
BioInvent Production AB
S-223 70 Lund, Sweden
Telephone: +46-46-168550, Fax: +46-46-2110806
Swedish company specializing in the development and production of monoclonal
antibodies, including antibody engineering, cellular technology, cell culture and
purification. Offering a choice of technologies available for continuous perfusion culture
(Cellex, Acusyst, Xcell, and Opticell systems).
P.O. Box 8045, Foster City, CA 94404, USA
Telephone: (415) 341-8787, Toll free: 1- (800) 341-8787 or , Fax: (415) 341-2299
Offer a wide variety of monoclonal and polyclonal antibodies for research purposes
produced in mice, rabbits, and goats. In vitro and cell culture technologies used in
production when possible.
Post Office Box 28
Lewisville, TX 75067-0028, USA
Telephone: (972) 420-8505, Toll free: (800) 227-0627, Fax: (972) 420-0442
Offer chicken polyclonal antibody services. Option to store eggs for an extra charge.
IgY extraction from one dozen eggs. Polyclonals also available from rabbits, sheep and
goats. Monoclonals produced by ascites in mice.
Cellco, Inc. (see Spectrum)
12321 Middlebrook Road, Suite 210, Germantown, MD 20874, USA
Telephone: (301) 916-1000, Toll free: (800) 253-1803, Fax: (301) 916-1010
Producers of CELLMAX®, artificial capillary cell culture systems designed to culture
hybridoma, lymphocytes, endothelial cells and other cell types.
Cellex Biosciences, Inc.
Perfusion Technolgies Division, 8500 Evergreen Blvd., Minneapolis, MN 55433, USA
Telephone: (612) 786-0302, Toll free: (800) 325-1112, Fax: (612) 786-0915
Specialize in in vitro cell culture technologies. Supplies cell culture apparatus, including ResCu-Primer HF and AcuSyst hollow fiber systems. Offer contract services for cell culture and purification from research scale to cGMP large scale production
The Centre for Biomedical Technology (BMTC)
Faculty of Medical Sciences
University of Groningen
P.O. Box 30.001
9700 RB Froningen, The Netherlands
Telephone +31-50 3614776 or +31 50 3615018, Fax: +31-50 3633113
Developed BIAcore an analytical biosensor for measuring interactions between molecules
in real time. BIAcore is capable of the following applications: measurement of
concentrations in serum and supernatant, affinity constants of antigen-antibody
interactions, screening hybridomas for IVD test kits, DNA-protein interactions,
functionality of modified proteins or antibodies, optimizing conditions, for column
chromatography, screening fractions of protein purifications. Service centre for in vitro
diagnostics offers the facility and expertise for production of recombinant proteins, PCR
development and PCR-ELISA detection, production of monoclonal and polyclonal antibodies.
CLB Biotechnology Services
Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
Telephone: +31-(0)20-512-3549, Fax: +31-(0)20-512-3550 (from U.S. 31-205123550)
Specialize in contract production of monoclonal antibodies intended for in-vivo
application and biosafety testing of biotechnological products. Antibodies produced using
Covance Research Products
P.O. Box 7200
Denver, PA 17517, USA
Telephone: (717) 336-4921, Toll free: (800) 345-4114, Fax: (717) 336-5344
Specialize in custom protocols for monoclonal and polyclonal antibody production. In vivo and in vitro methods used. Services include hybridoma development, peptide synthesis, immunoassay development and testing, ELISA testing, basic primary cell
and antibody characterization, purification, and packaging.
154 Technology Pkwy., Norcross, GA 30092, USA
Telephone: (770) 368-9500,Titermax Telephone: (800)-345-2987, Fax: (770) 447-8875
Produces of Titermax®, a synthetic alternative to Freund's adjuvant for monoclonal and
polyclonal antibody production.
600 College Rd., E., Princeton, NJ 08540-5308, USA
Telephone: (609) 987-8200, Fax: (609) 452-2975
URL for catalog and newsletter: http://www.cytogen.com
Research and development of diagnostic and therapeutic substances such as monoclonal
antibodies for cancer patients. Antibodies produced using hollow fiber bioreactors.
Antibodies purified to a high purity suitable for in vivo use. Contract manufacturing of
27 Cannon Road, Wilton, CT 06897, USA
Telephone: (203) 762-0279, Toll free: (800) 676-2927, Fax: (203) 762-2378
Manufacturers of a simple "No-Mouse" system in which a gas permeable bag is
used to grow hybridoma cells for monoclonal antibody production. No special machinery
required other than a tissue culture hood, 37C incubator, and a low speed centrifuge.
Eramus Centre for Animal Research (EDC)
Erasmus University (FGG)
P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands
Telephone: +31-(0)10-4087587, Fax: +31-(0)10-4361425 (from U.S. 31-104361425)
Produce monoclonal antibodies in an artificial culture system (Integra
Biosciences Technomouse) upon request and for experimental use only. Most
monoclonal antibodies produced in protein free medium without the use of
Facilitair Hybridoma Laboratorium
Institute for Infectous Diseases and Immunology
Faculty of Veterinary Medicine
Yalelaan 1, 3584 CL Utrecht, The Netherlands
Telephone: +31 30 2531872 or /4358, Fax: +31 30 2533555 (from U.S. 31-302533555)
E-mail: firstname.lastname@example.org or email@example.com
Producers of MoAbs in protein free medium in bulk culture and concentrated by
ultra-filtration (30 kD filter). Product has a purity of +/- 80%. Higher percentage purity
is available on request.
Fuzhou Maxim Biotech, Inc.
566 Gunyeh Rd.
Fuzhou, Fujian 350002, PR China
Telephone: +86 591 3732741, Fax: +86 591 3720685
Produce the EZInetTM phage display cDNA library kit which utilizes
filamentous phage, M13, to express foreign peptides or proteins.
Goodwin Biotechnology Incorporated
1850 NW 69th Ave., Plantation, FL 33313, USA
Telephone: (954) 321-5300, Fax: (954) 587-6378
GBI is a cGMP compliant contract manufacturer that assists companies
developing monoclonal antibodies and recombinant proteins in mammalian
cell culture. Our focus is to provide services that our compliant,
scalable, and cost effective. GBI is fully integrated and our “fast track”
manufacturing strategies have enabled us to deliver vialed product to
clients in as little as seven months after transfer of a cell line to GBI.
Services offered by GBI include cell line engineering, clone selection,
media studies, process development, cell banking, bioreactor production,
purification, monoclonal antibody conjugation (and enzymatic digestion)
and aseptic filling. These services are offered in support of your fully
integrated projects (providing you as close to a turn-key approach as
possible in biologics manufacturing) or as stand-alone services. GBI’s
manufacturing activities are supported by analytical testing, stability
studies, project management, and unparalleled regulatory support.
Regulatory support includes preparation of CMC sections for IND
applications (or foreign equivalents), and distribution of your product to
clinical trial sites.
Harlan Bioproducts for Science, Inc.
P.O. Box 29176
Indianapolis, IN 29176, USA
Telephone: (317) 894-7536, Toll free: (800) 972-4362, Fax: (317) 894-1840
Specialize in the custom production of polyclonal and monoclonal antibodies, in
vivo and in vitro. Offer cGMP and non-cGMP production, hybridoma
development, MAP testing, purification, endotoxin testing and other immunological
IDEC Pharmaceuticals Corp.
11011 Torreyana Rd.
San Diego, CA 92121, USA
Telephone: (619) 550-8500, Fax: (619) 550-8750
URL: http://www.idecpharm.com (under construction)
Research and development of monoclonal antibodies. Phage display technologies
investigated. Alternative adjuvant ProVax used in cancer studies. Large scale antibody
56 Evergreen Dr., Portland, ME 04103-1066, USA
Telephone: (207) 878-2770, Fax: (207) 878-2117
Develop and manufacture cow milk-derived passive antibody products. Rabbits and cows
used for polyclonal antibody production. Tissue cultures used in vaccine development.
Applications include a product to prevent scours in calves and others to prevent human
Institute of Laboratory Animal Science
University of Zurich
Winterthurerstrasse 190, 8057 Zurich, Switzerland
Telephone: +41 1 257 54 52, Fax: +41 1 257 57 03 (from U.S. 41-1257575703)
Generate MAB in various sized hollow fiber bioreactors and roller bottles. Hybridoma
lines can be sub-cloned to increase yields if necessary. Customers receive the required
amount of MAB as a crude bioreactor harvest. FCS-free culture available if the hybridoma
line has previously been adapted to this condition by the customer.
INTEGRA Biosciences (Multiple Addresses)
Lampire Biological Laboratories, Inc.
INTEGRA Biosciences AG
P.O. Box 74, CH-8304, Wallisellen, Switzerland
Telephone: (41) +1 8 77 46 46, Telefax: (41) +1 877 46 00
INTEGRA Biosciences AG
P.O. Box 74, CH-8304, Wallisellen, Switzerland
Telephone: (41) +1 8 77 46 46, Telefax: (41) +1 877 46 00
INTEGRA Biosciences GmbH
Ruhberg 4, D-35463 Fernwald, Germany
Telephone: (49) 6404 80 90, Telefax: (49) 6404 58 65
INTEGRA Biosciences S.a.r.l.
4, rue de lendemain, B.P. 8886, F-95898 Cergy le Haut Cedex, France
Telephone: (33) 1 3446 7171, Telefax: (33) 1 3446 7179
INTEGRA Biosciences Ltd.
Unit 9, Ascot Industrial Estate, Icknield Way, Letchworth, UK-Hertfortshire, SG6 1TD
Telephone: (44) 1462 48 65 48, Telefax: (44) 1462 48 66 78
INTEGRA Biosciences Inc.
10097 Tyler Place, Suite 10, Ijamsville, MD 21754, USA
Telephone: 1 (301) 874-5790, Telefax: 1 (301) 874-5799
Web Page: http://www.integra-biosciences.com
hollow fiber "in vitro" system, has been used successfully for years for
the production of monoclonal antibodies and for the expression of cell
products. In this system,
separation of cultivation and nutrient/oxygenation chambers is via hollow fibers in combination with membranes through which gases may diffuse. Optimal media utilization, direct oxygenation and yields of up to 500 mg of monoclonal antibody per month are
In the same unit up to five different cell lines can be cultivated at the same time. TECNOMOUSE truly is an alternative to the production Mab in mice.
a compartementalized cell culture system based on membrane technology, is
another product in INTEGRA's line of alternative cell cultivation products
that has just been
This system can cultivate up to 108mg of Mab per month. The membrane technology greatly reduces the serum consumption and especially the time spent for purfication. The CELLine is available in three
different sizes, is disposable, efficient and cost effective. A recently published article in the Scientist magazine describes the advantages of this system.
P.O. Box 270, Pipersville, PA 18947, USA
Telephone: (215) 795-2838, Fax: (215) 795-0237
Develops and produces monoclonal and polyclonal antibodies. Uses ascites production and
bioreactor technologies. Catalog available. Monoclonal animal models include mice, rats,
and hamsters. Polyclonal animal models are rabbits, chickens, goats, sheep, and donkeys.
Custom antibodies can be designed and produced using rats, cows, guinea pigs, and horses.
Lazar Research Laboratories, Inc.
731 North La Brea Avenue Suite 5
Los Angeles, CA 90038, USA
Telephone: (213) 931-1204 or 001-213- 931-1204 (outside U.S.),Toll free: (800) 824-2066,
Fax: (213) 931-1434 (outside U.S. and Canada, dial 001 country code before the Telephone
Offer the Ultra M Micro Bioreactor System for sale. Can convert standard six well
cultura plate or T-flasks into a continuous flow bioreactor system.
Maine Biotechnology Services, Inc.
1037R Forest Avenue, Portland, ME 04103, USA
Telephone: (207) 797-5454, Fax: (207) 797-5595
Produces customized monoclonal and polyclonal antibodies for diagnostic companies and
researchers. Several hundred antibodies are listed in the catalog. Bioreactors and mice
are used for monoclonal production. Polyclonal antibodies are produced from sheep, goats,
National Institute of Public Health and the Environment (RIVM)
Laboratory for the Control of Biological Products (LCB)
P.O. Box 1, 3720 BA, Bilthoven, The Netherlands
Telephone: +31 30 2743697, Fax: +31 30 2744420 (from the U.S. 31-302744420)
Available to provide information on in vitro production of monoclonal antibodies.
Knowledge of cell culture, roller bottle, and hollow fiber system technologies.
New England Biolabs, Inc.
32 Tozer Road
Beverly, MA 01015, USA
Telephone: (508) 927-5054, Toll free: (800) 632-7799, Fax: (508) 921-1350
Offer phage display peptide library kits displayed on bacteriophage M13.
Office of Biotechnology
Iowa State University
Ames, Iowa 50011-3260, USA
Telephone: (515) 294-2472, Fax: (515) 294-0453
E-mail: firstname.lastname@example.org or email@example.com
Offer bulk monoclonal antibody production in bioreactors or ascites production in mice.
Federal Agency for Sera and Vaccines
Department of Veternary Medicine
D-63225 Langen Neurott, Germany
Telephone: (49) 6103-77/77-0, Fax: (49) 6103/77-123 (from U.S. 49-610377123)
Research conducted on alternative adjuvants for vaccine development and research
immunizations with little side effects.
11021 Via Frontera #203, San Diego, CA 92127, USA
Telephone: (619) 675-2405, Toll free: (800) 929-2114 or , Fax: (619) 592-1509
Develops and supplies monoclonal and polyclonal antibodies to an extensive range of
antigens for research laboratories and healthcare industry. Offers custom antibody
development (monoclonal and polyclonal), ascites production, and in vitro antibody
production services. New products include culture media for hybridomas, immunoassay kits,
ascites production kits, and hybridoma development kits.
Ribi ImmunoChem Research, Inc.
553 Old Corvallis Road, Hamilton, MT 59840, USA
Telephone:(406) 363-6214, Toll free: (800) 548-7424, Fax: (406) 363-6129
Manufactures the Ribi Adjuvant System (RAS). RAS is appropriate for use in a variety of
laboratory animals such as mice, rats, guinea pigs, rabbits, goats and non-human primates.
Independent comparative studies have shown that RAS is an effective adjuvant without the
toxic side effects associated with the use of Freund's adjuvant.
Scantibodies Laboratory, Inc.
9336 Abraham Way
Santee, CA 92071, USA
Telephone: (619) 258-9300, Fax: (619) 258-9366
Offer custom in vitro monoclonal antibody production using a variety of bioreactors.
Ascites production in mice.
Spectrum® U.S. Headquarter
23022 La Cadena Drive
Laguna Hills, CA 92653-1352, USA
Telephone: (714) 58-3500 or toll free 1-(800) 654-0111, Fax: (714) 855-6120
Spectrum® has merged with Cellco, Inc. (see Cellco), makers of an artificial capillary
system for in vitro production of monoclonal antibodies, proteins, and viruses. Spectrum
is a supplier of dialysis and ultrafiltration membranes used for biomedical research,
molecular biology, and clinical diagnostics.
780 Park North Blvd., #110, Clarkston, GA 30021, USA
Telephone: (404) 296-5595, Fax: (404) 296-0052
Provides monoclonal and polyclonal antibodies to pharmaceutical companies that develop
diagnostics. Locate and recruit antibodies for use as test kit controls. Antibodies are
human subject derived such as rabies immunoglobulin and hepatitis A and B.
Sierra BioSource, Inc.
1180-C Day Rd., Gilroy, CA 95020-9308, USA
Telephone: (408) 847-5444, Fax: (408) 847-5044
Produces cell lines for clients. Uses some in vitro techniques for monoclonal antibody
production. Monoclonal models include mice, rats, and humans. Polyclonal antibodies
produced on demand from rats, rabbits, and guinea pigs.
TNO Prevention and Health
Immunological and Infectious Diseases
P.O. Box 2215, 2301 CE, Leiden, The Netherlands
Telephone: +31.71.518.1431, Fax: +31.71.518.1901 (from U.S. 31-715181901)
Offer complete services to obtain suitable site-specific poly- and monoclonal
antibodies using antigen or synthetic peptides including: selection of epitopes, synthesis
of peptides, construction of peptide conjugates for immunization, and development of
selection assays. MAbs are produced using in vitro methods.
Unisyn Technologies Inc.
25 South St., Hopkinton, MA 01748, USA
Telephone: (508) 435-2000, Toll free: (800)-4UNISYN, Fax: (508) 435-8111
Manufacture hollow fiber bioreactor instruments and accessories and protein
purification products for monoclonal antibodies and recombinant protein production. GMP
contract service facility for clients on a research or full outsourced basis.
2408 Timberloch Place, B4
The Woodlands, TX 77380, USA
Telephone: (281) 367-5892 or toll free 1-888-448-4837, Fax: (281) 363-8796
Producers of Z-maxTM and ImmuMax SR, alternatives to Freund's
adjuvants. Z-maxTM was designed specially for use with HIS tagged recombinant
proteins, while ImmuMax SR was developed to elicit lasting titers to both
native and recombinant proteins as well as synthetic peptides.